Cells, Free Full-Text
Por um escritor misterioso
Last updated 21 setembro 2024
Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when dysregulated. Here we aimed at understanding the role of microRNA-223 in orchestrating pulmonary inflammation during pneumococcal pneumonia. Serum microRNA-223 was measured in patients with pneumococcal pneumonia and in healthy subjects. Pulmonary inflammation in wild-type and microRNA-223-knockout mice was assessed in terms of disease course, histopathology, cellular recruitment and evaluation of inflammatory protein and gene signatures following pneumococcal infection. Low levels of serum microRNA-223 correlated with increased disease severity in pneumococcal pneumonia patients. Prolonged neutrophilic influx into the lungs and alveolar spaces was detected in pneumococci-infected microRNA-223-knockout mice, possibly accounting for aggravated histopathology and acute lung injury. Expression of microRNA-223 in wild-type mice was induced by pneumococcal infection in a time-dependent manner in whole lungs and lung neutrophils. Single-cell transcriptome analyses of murine lungs revealed a unique profile of antimicrobial and cellular maturation genes that are dysregulated in neutrophils lacking microRNA-223. Taken together, low levels of microRNA-223 in human pneumonia patient serum were associated with increased disease severity, whilst its absence provoked dysregulation of the neutrophil transcriptome in murine pneumococcal pneumonia.
Cell-free Macromolecular Synthesis
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Cell-free gene expression: an expanded repertoire of applications
Cell-free Fetal DNA — A Trigger for Parturition
Ds Kumar Strömungsmechanik Pdf Kostenloser Download - Colaboratory
Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system, Inflammation and Regeneration
Cells, Free Full-Text
Sequencing of Circulating Cell-free DNA during Pregnancy
Cells, Free Full-Text
PDF) Protein structural biology using cell-free platform from wheat germ
Textile-embedded cell-free biosensors
Recomendado para você
-
Gamificação para um trabalho melhor - Robbyson/AeC21 setembro 2024
-
robbyson Sticker for iOS & Android21 setembro 2024
-
Index of /media/out21 setembro 2024
-
MetaTrace on X: Meet Trace Ads 📢📰 A chance for brands to shine21 setembro 2024
-
Robson AeC by Fernando Parreiras21 setembro 2024
-
Robbyson21 setembro 2024
-
AeC - Relacionamento com Responsabilidade - Quem aí tá bombando no21 setembro 2024
-
Transformando agentes em campeões no atendimento ao cliente21 setembro 2024
-
New Colorado College Arena Links Campus, Downtown21 setembro 2024
-
Robbyson Mobile beta 1.4.1 APK Download - Android Productivity Apps21 setembro 2024
você pode gostar
-
Pizza Cooking Simulator: Kitchen & Cooking Game APK pour Android21 setembro 2024
-
Sirius The Jaeger Yuliy Mikhail Angels Anime Acrylic Keychain Keyring Strap Cute21 setembro 2024
-
EVENTO DA MOCO COM 110% DE BÔNUS DE DIAMANTES NO HYPE21 setembro 2024
-
Transferir partição WINDRIVER para o disco rígido do sistema operacional21 setembro 2024
-
Gold Mining in the Klondike in Gold Rush The Game Xbox21 setembro 2024
-
Drama Mandarin - Rising With the Wind (2023)21 setembro 2024
-
V. Guimarães é o primeiro campeão do Liga Portugal Legends - V21 setembro 2024
-
Burnt Mikhail Tal Chess Pieces in Burnt Boxwood and Boxwood- 3.7521 setembro 2024
-
Valvrave the Liberator Trailer21 setembro 2024
-
Adultman energy (Benny Watts from Queen's Gambit) : r/BoJackHorseman21 setembro 2024